I have now using the NtfsDisableLastAccessUpdate=0 during 2 months
First thing, system is very slower.
Second thing, today i've made 2 standard defrag.
The picture below shows you the system with the registry key set to 0
The picture below shows you the system with the registry key set to 1
As you can see, the use of this registry key (set to 0) mades more files moved in the spacehog area.
Considering the global system performances, I will set this registry key to 1 even there is more files in the zone 2.