..........All I am saying is that with a single partition you can organize the data on the disk for the best possible speed. With multiple partitions you have no such choice.
I am afraid it is not fully true.
No data can have best possible speed without denying best possible speed to other data.
This influence is direct by file placement, and indirect in way how partition, file system and the whole disk are defined and managed.
The key to optimization is to accept such a loss, allowing bigger gain to appear.
Creation of 2nd partition is the same kind of gaining loss,
as accepting gain loss for spacehogs, putting them to spacehogs.
Saying files in the 2nd partition suffer performance loss
is like saying files in spacehogs suffer performance loss.
Both is true, and both is true intentionally.
Overall performance means denying it for some.
The 2nd partition is little cutting wings from files they do not need them,
to add wings to files left in the 1st one that do need them much more.
It is slowing down "slow spacehogs" in order to speeding up "fast spacehogs".
An not only spacehogs, concerning ways Windows likes to place files.
The 2nd partition is forcing Windows to keep operations in compact fast disk area.
The way how files are placed by part. layout and MD scripts is just one side of the thing.
The other one is what happens in time between.
Single partition becomes a bigger jungle.
More was stated above in the thread.